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Article . 2012
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Sexual Dimorphism of Corpus Callosum Occurs in Human Foetuses

Authors: M. Pramila Padmini; B. Narasinga Rao;

Sexual Dimorphism of Corpus Callosum Occurs in Human Foetuses

Abstract

{"references": ["1. Bishop KM, Wahlsten D: Sex differences in the human corpus callosum: myth or reality? Neuroscience & Biobehavioral reviews, 1997; 21(5):581-601", "2. DeLacoste-Utamsing C, Holloway RL: Sexual dimorphism in the human corpus callosum. Science, 1982;216(4553):1431-1432.", "3. Dougherty RF, Ben-Shachar M, Deutsch G, Potanina P, Bammer R, Wandell BA: Occipital-Callosal Pathways in Children: Validation and atlas development. Annals of the New York Academy of Sciences, 2005;1064:98-112", "4. Dubb A, Gur R, Avants B, Gee J: Characterization of sexual dimorphism in the human corpus callosum. Neuroimage, 2003;20(1):512-519.", "5. Gupta E, Khan AA, Ramesh Babu CS, Lalwani R, Aneja S: Sexual dimorphism of splenial thickness of corpus callosum. Current Neurobiology, 2011;2(1): 63-66.", "6. Hamilton WJ, Boyd JD, Mossman HW: Growth of Embryo and foetus; Development of external form; estimation of embryonic and fetal age. In : Human Embryology, Prenetal Development of form and function. WJ Hamilton & HW Mossman (Eds.); 4th Edn.; 1972;pp.172-177.", "7. Koshi R, Koshi T, Jeyaseelan L, Vettivel S: Morphology of the corpus callosum in human fetuses. Clinical Anatomy, 1997;10(1):22-26.", "8. Weis S, Weber G, Wenger E, Kimbacher M: The Controversy About a Sexual Dimorphism of the Human Corpus Callosum. International Journal of Neuroscience, 1989;47(1-2):169-173."]}

Sexual dimorphism in human corpus callosum is controversial, and only a limited number of studies have been done on foetuses. Corpus callosum of 50 foetal brains, 25 male and 24 female were studied however, one foetus with undifferentiated sex, was excluded from the present study. The crown rump length (CRL) and the brain weight of these foetuses ranged from 5 to 39 cm and 10 to 550 gm. Brain was divided into two equal halves by median section after fixation. The length of the corpus callosum, pre-callosal and post-callosal lengths, were measured on the medial aspect of each cerebral hemisphere. The thickness of splenium was measured in the sagittal section. The brain weight increased with increase in the CRL length in all the foetuses. The average length of the corpus callosum was more in males than in females. The z test value was 1.3871, which is not significant. The thickness of splenium was more in females than male. The z test value was 2.28, which is highly significant. Sex difference was not observed in any of the other parameters.

Keywords

Corpus callosum, Cerebral hemispheres, Splenium, Dimorphism

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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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