This article aims to analyze the changes in the urban network and the expansion of the pioneering fronts in the South of Amazonas connected by the BR-319 (Manaus-Porto Velho) and BR-230 (Transamazônica) highways, and also the Southwest of Acre which has highways paved roads such as the BR-364 (between Rio Branco and Cruzeiro do Sul) and BR-317 (between Rio Branco and Assis Brasil). For this, a bibliographical survey was carried out, fieldwork was carried out in 2022 and the elaboration of thematic maps to represent the new identified network contents. From the construction of understanding of the desired process, it was possible to propose a periodization for the study area that contemplates from the beginning of the markedly fluvial colonization until the present moment with a strong link to the road system and the advance of the pioneer strip. From primary data, a new dynamic of circulation of the urban network in the South of Amazonas was observed, with new flows that are articulated with the active pioneer front.