The study examined the impact of fossil fuel emissions on the quality of life and health of individuals in South-South Nigeria. The specific objectives sought to; Identify sources of fossil fuel emissions, analyze the cost-benefit implication of fossil fuel emissions, identify factors that are responsible for the frequent usage of fossil fuel, Identification of alternative energy sources, and Remediation of the impact of fossil fuel emissions in south-south Nigeria. A survey design was adopted for the study. A primary source of data was adopted for the study. A questionnaire and interview were used to collect data for the study. The Population is 4,112,445 people. The Sample sizes were determined using Yamane (1973) a standard statistical formula. The total sample size is 399. The data were analyzed using analysis of Variance (ANOVA). The result revealed that Fossil fuel emissions are bad and their impacts on the quality of human being lives are dangerous, also impact on the health of living organism are deadly. Fossil fuel emissions have an unhealthy impact on the environment, such as Air and Water pollution which causes acid rain, eutrophication (food nutrient oxygen deficiency that causes harms and genetic mutilations) which harms the ecosystem by covering oxygen levels and damage to crops, forest, and wildlife. We concluded that fossil fuel emission causes some harmful ailments like cancer and respiratory tract infections diseases. We recommended among others that government agencies should sensitize rural individuals to the dangers of fossil fuel emission.