This study examined the impact of anthropogenic activities on ecosystem stability in Gashaka-Gumti National Park. The study employed survey research design. Questionnaires were used to solicit information from the respondents. 156 structured 5-point Likert scale questionnaire were administered to 158 staff. However, only 156 were later retrieved and their responses carefully analyzed using IBM-SPSS version 25 software in conjunction with descriptive statistics. The results show that anthropogenic activities have led to the destruction of wildlife, agricultural resource degradation, draining of streams/rivers, destruction of habitat, air pollution and ecosystem instability. The study recommended the need for Federal Government of Nigeria to employ more staff with adequate training for effective policing of the Park as the current number of 259 staff cannot effectively manage the Park which covers 6,731Km2 of land area.