Lumpy skin disease (LSD) has been portrayed as a frightening threat to cattle population. It is an arthropod borne viral disease, caused by lumpy skin disease virus (LSDV), a member of Capripox virus genus of Poxviridae family and characterized by fever, anorexia, and characteristic nodules on the skin mucous membrane of mouth, nostrils, rectum, genital, udder and drop in milk production. It is a transboundary disease of the economic importance affecting cattle and water buffaloes causes high morbidity and low mortality. The only method for successful control is early diagnosis, strict quarantine, vector control and efficient vaccination.