“In person cognitive rehabilitation versus telerehabilitation in patients at risk of dementia: How can cognitive reserve, lifestyle habits, and other factors explain this choice?” to be submitted to Frontiers in Psychology journal. Dataset evaluated how patients’ preference for in presence cognitive rehabilitation program (CoRe) or telerehabilitation one (HomeCore) could be associated to different factors: cognitive reserve and lifestyle habits, sociodemographic characteristics, cognitive functioning, and mental health. Considering those factors could facilitate the discrimination a priori between patients who will potentially prefer TR, by ensuring a high probability of treatment adherence and then success. To this end, we used explorative descriptive approach, logistic regression, and non-parametric models to explore the overall contribution of each variable.