As the use of engineered nanomaterials continues to grow, there is a pressing need to improve the safety and sustainability of these materials through the incorporation of safety-by-design (SbD) and safe- and sustainable-by-design (SSbD) principles. In this field, high-throughput, in-vitro screening methods are essential for evaluating toxicity and identifying potential hazards. In this presentation, we showcase two new technologies developed under the SABYDOMA project to accelerate the wear of engineered nanomaterials and perform high-throughput screening on nanomaterial leachate media. Combined, these technologies can form a powerful tool to aid the understanding of the toxic properties of nanomaterials at the point of leaching.