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Toxicological evaluation of co-exposure to microplastics and benzo(a)pyrene on a 3D human bronchial epithelium model

descriptionPublicationkeyboard_double_arrow_right Conference object , Other literature type , Article 01 Jan 2023Publisher:ZenodoFunded by:EC | PlasticsFatE

Authors: Mawas, Safaa; Miremont, Dorian; Izabelle, Charlotte; Bui, Linh Chi; Renault, Justine; Devineau, Stéphanie; Boland, Sonja;

doi: 10.5281/zenodo.8038706 , 10.5281/zenodo.8038705

Toxicological evaluation of co-exposure to microplastics and benzo(a)pyrene on a 3D human bronchial epithelium model

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Abstract

Airborne microplastics (MPs) have been recently detected in human lung tissue, but their fate and impact on airways is still unrevealed. Our study focuses on the impacts of polyethylene terephthalate(PET) or polystyrene (PS) alone or combined with BaP on an in vitro model of human bronchial epithelium that we recently developed to study short and long-term effects, on air-liquid interface (ALI) grown Calu-3 cell line (lung adenocarcinoma patient cells).

Related Organizations

French National Centre for Scientific Research
France
University of Paris
France
Unit of Functional and Adaptive Biology
France

Keywords

lung tissue, microplastics, air-liquid interface (ALI), Calu-3, polyethylene terephthalate(PET), benzo(a)pyrene, polystyrene (PS), human bronchial epithelium, toxicology

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