Read it on medium (recommended). In the unending coevolutionary dance between plants and microbes, each player impacts the evolution of the other. This article provides an overview of the burgeoning field of Evolutionary Molecular Plant-Microbe Interactions (EVO-MPMI), tracing its progression from foundational science to practical implementation. It delves into central concepts and methodologies, and offers a snapshot of current research. Moreover, the review sheds light on the practical applications of EVO-MPMI, particularly within the realm of disease control. Looking ahead, we discuss potential future trajectories for EVO-MPMI research, spotlighting the innovative tools and technologies propelling the discipline forward.