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A low power high performance CMOS instrumentation amplifier is designed through the operational amplifier (op-amp) used for biomedical applications. It consists of a low power operational amplifier with three stage op-amp structure. First two stages consists of input stage and drive stage and the third stage consist of output stage. In biomedical applications, the instrumentation amplifier (IA) requires high gain, CMRR with less noise and low power optimization. The design and analysis of the parasitic effects and the other parameters is taken and the instrumentation amplifier is found to have better performance in all aspects. With the varying width and length of the transistor, we obtain the excepted gain and CMRR. The instrumentation amplifier improves the input signal gain and CMRR to have the excepted outcome of the biomedical signal processing application. The proposed design is implemented in CMOS 180nm technology using cadence Virtuoso and the simulation is obtained through spectre simulator.