Abstract: Widespread applications of pesticides such as Lambda cyhalothrin to boost crops production have frequently led to contamination of the fresh water ecosystem in Nigeria. In this study, Clarias gariepinus were exposed to sub-lethal concentrations of Lambda-cyhalothrin pesticide. The 96 h LC50 of lambda cyhalothrin to the fish was estimated at 3.98mgl-1. Mortality of 100% and 10% were observed in fish exposed to 12.00 mg l-1 and 1.25 mg l-1 of Lambda cyhalothrin respectively as compared to no mortality recorded in the control group. Varying degrees of abnormal behaviours like air gulping, hyperactivity, erratic movement, skin discoloration and jerky movements were observed during the 96 h exposure period of the fish to Lambda compared to the control. There was no significant difference (p>0.05) between the values of water quality assays in control and treated group. Exposure to sub-lethal concentrations of Lambda cyhalothrin at 0, 0.25, 0.50 and 1.00 mgl-1 and for 15 days at 5 days intervals that is 5, 10 and 15days led to changes in the antioxidant physiological functions in the fish in comparison to the control. The result for the oxidative biomarkers showed there was increase in the mean values of Glutathione peroxidase (GPX) and Reduced glutathione (GR) with increase in the concentration of the toxicant when compared with the control. Also, there was significant decrease in the values of the Super oxide dismutase (SOD) and Catalase (CAT) with lipid peroxidase (LPO) showing no significant difference at P<0.5 with increase in concentrations of the toxicant when compared to the control. The study reports that lambda could cause oxidative and physiological dysfunction in Clarias gariepinus. The biomarkers measured could be useful tools for monitoring effects of other pesticides on aquatic organisms. However, further studies could be done to investigate their mode of action to strike a balance between protection of aquatic biota and discharges of these pesticides and their metabolites to aquatic environments. Keywords: Impact, Antioxidant parameters, Lambda, pesticide. Title: IMPACT OF LAMDA LAMDA-CYHALOTHRIN ON THE ANTIOXIDANT PARAMETERS OF Clarias gariepinus Author: Nwamba, Helen Ogochukwu, Ogbonna Obiageli Annastesia, Anukwu John Uchenna International Journal of Novel Research in Life Sciences ISSN 2394-966X Vol. 10, Issue 3, May 2023 - June 2023 Page No: 15-25 Novelty Journals Website: www.noveltyjournals.com Published Date: 23-May-2023 DOI: https://doi.org/10.5281/zenodo.7962279 Paper Download Link (Source) https://www.noveltyjournals.com/upload/paper/IMPACT%20OF%20LAMDA%20LAMDA-CYHALOTHRIN-23052023-9.pdf

International Journal of Novel Research in Life Sciences, ISSN 2394-966X, Novelty Journals, Website: www.noveltyjournals.com