Pneumonia is an acute lung infection caused mainly by bacteria. The primary therapy given for pneumonia is antibiotics. Antibiotics are chemical compounds produced by a microbe that kill or inhibit the growth of other microbes. Studies in several countries have shown that more than 70% of patients were prescribed antibiotics and almost 90% received unnecessary antibiotic injections. The mortality rate and treatment failure will be higher if the prescription of antibiotics for patients is not following the established guidelines. This study aims to determine the antibiotic usage profile in pediatric pneumonia patients. The descriptive study with data collection through medical records of inpatient installation in 2020-2021, involving 30 patients retrospectively. The study showed that most pediatric pneumonia patients were males, with 21 patients (70%). The age range of most pediatric pneumonia patients was 13-60 months, with 16 patients (53.3%). The most common single antibiotic used in pediatric pneumonia patients at Dr. M. Djamil Hospital was ceftriaxone, with 13 patients (43.33%). In comparison, the most common combination antibiotic used was ampicillin and gentamicin with ten patients (33.34%).