The Co-Creation Database groups scientific references on co-creation. It mainly contains the title, abstract, DOI, and authors. Two versions are available: Version 1.5 includes 13,501 references, from PubMed, ProQuest and CINAHL, from January 1970 to November 2021. Available in RIS (Research Information Systems) format and CSV (CSV UTF-8). Quality metrics: 9.38% false negatives; 20.35% false positives. Version 2.0 is an update from a classification model trained with version 1.5. It includes references from Scopus and Web of Science from January 1970 to March 2023, with an update of the previous databases used for version 1.5 from December 2021 to March 2023. Two CSV (CSV UTF-8) files are available. The "Co-Creation Database v2.0 - full.csv" combines the last version, 1.5 and the update, with 52,821 references. The file "Co-Creation Database v2.0 - adding.csv" has only the update, with 39,219 references. Quality metrics: 13.98% false negatives; 36.43% false positives. To perform your search: we recommend you extend your search to the title and abstract since some data are initially missing. The RIS file can be uploaded to any references manager (e.g., Zotero, Mendeley, etc.), where you will have the feature to search. For example, here is the link for advanced search instructions in Zotero: https://www.zotero.org/support/searching. Additionally, You can run a Boolean search for CSV files using a Python script. To improve the database in further updates: we make available an online form to submit any irrelevant references you may find or to submit any relevant reference not inside the last version. The form is available at the following link: https://forms.office.com/e/6vu9X0kBcw It was produced as part of Health CASCADE, a Marie Skłodowska-Curie Innovative Training Network funded by the European Union's Horizon 2020 research and innovation programme under Marie Skłodowska-Curie grant agreement n° 956501. The work is made available under the terms of the license CC-BY-NC-4.0 (Creative Common Attribution - NonCommercial - NoDerivatives 4.0 International).