Increasing the effectiveness of treatment by improving the reparative processes of patients with drug resistant destructive pulmonary tuberculosis (DR DPT) is one of the main issues of medicine. One of such methods used in the complex treatment is collapsotherapy. The aim of the study was to evaluate the effectiveness of colapsotherapy in the complex treatment of patients with DR DPT. For this purpose, 16 paients with DR DPI were examined. Full sensitivity to all anti-tuberculosis drugs (ATD) was observed in 23 patients (03, mono- and polyresistance in 25 patients (32.9% and multiresistance in 28 (36.8% patients. Patients were divided into two groups: I group basic group, 34 patients, who were prescribed the treatment with ATD taking into account the sensitivity test with the use of collapsotherapy and group Efcontrol group) consisted of 42 patients, who only received ATD, also taking into account sensitivity. As a result of the study, it was found that the use of collapsotherapy in patients with DR DPT in the complex treatment increases the effectiveness of treatment. Using sputum mmicroscopy, persistent abacilation was observed at the end of the second month in 79.4% and at end of the fourth month in 94.1% of patients (52.4% and 66.79% in the control group, respectively. It was also found that the use of collapsotherapy for patients with DR DPT led to the closure of the decay cavities in 58.8% (in the control group 23.1 %). Thus, we came to the conclusion that the use of collapsotherapy in the complex treatment of newly diagnosed DR DPT, taking into account the test for sensitivity to antibacterial drug, increases the effectiveness of treatment.