Introduction: Medical students face a variety of stress at medical school, which includes high academic demands, workloads, tough curricular aspects, learning settings, personal life events all are contributing stress among students . When compared to other students academic stress in medical students were found significantly high along with high level of anxiety and depression. Methods: The present study involved a total of 40 male students were chosen for the study. Aged 18-21years of first year MBBS students of Srinivas institute of medical science and research center. Parameters such as height, weight, temperature, pulse rate , systolic blood pressure and diastolic blood pressure were taken before and after examination on the same day . Result: Out of 40 male subjects, The mean and standard deviation of BMI in study group of males is 24.4 ±4.54 ,the mean and standard deviation of pulse rate before and after examination was 81.7±13.54 and 75.4±8.50 there was highly significant increase in P value (P<0.0001) respectively .The temperature before and after examination 32.9±1.38 and 32.1±1.42.there was significant increase in P value (P<0.002) respectively . The mean and standard deviation of systolic blood pressure before and after examination was128±3.76 and 110±6.55 there was highly significant increase in P value (P<0.0001) respectively and Diastolic blood pressure before and after practical examination was 86.55±3.14 and 79.55±2.66 there was highly significant increase in P value (P<0.0001) respectively .Conclusion: In order to avoid the long-term negative consequences of elevated stress levels on future doctors' physical and mental health, medical students should receive the proper counseling and stress-relieving activities. and medical curriculum should include mentoring and training assistance programs. Keywords: Examination Stress, Medical Students, Cardiovascular Vital Parameters, Basal Metabolism, Body temperature