Vitamins are essential substances for human health ,if the intake is not adequate, special dietary supplements are exist like multivitamins. The increased interest in functional materials of natural origin are resulted in high demand for preservative free, clean label or natural ingredient based products. The gummy vitamin supplements are more acceptable to consumers and have fewer limitations compared to other dosage forms. The main object of this review study was to investigate the complete analysis of multivitamin tablets and capsules by HPLC analysis for determination of individual vitamin identifications as well as in gummies also and evaluate bioequivalence between both formulations through the chemical, pharmaceutical and bioequivalences of multivitamin tablets and gummies. Background: Article searching: Medline(pubmed), web of knowledge, Scopus, PsycINFO, upto date, web of science, science direct, online books, and different websites were searched for the Terms performing to multivitamin(vitamin/mineral/multivitamin/dietary supplement/gummy) and the terms relating to bioequivalence, HPLC, pharmaceutical equivalence of the multivitamin etc. forward and backward searching was also performed on trials meeting the inclusion criteria ,to be considered inclusion trials must be randomized and placebo controlled. Raw data analysis: Data regarding bioequivalence studies of the gummies like vitamin D content and vitamin E,B12, folate in gummy and tablet formulations screening laboratory values, Cmax , AUCs and blood concentrations at different time intervals which were in the reference articles directly entered. Considerations: Inclusion criteria through the previous articles included healthy adults age between 18-45 years old male and females, BMI of 18.5-29.9kg/m2 for bioequivalence studies and exclusion criteria includes woman who are pregnant and breastfeeding, and patients who has the history of gastrointestinal diseases, irritable bowel syndrome, metabolic diseases, kidney stones, smokers, anemia patients etc.. Keywords: Multivitamin, gummies, HPLC, chewable, mobile phase, stationary phase, calibration, linearity, range, selectivity, gelatin, pectin, agar, wavelength, bioequivalence, chemical equivalence, pharmaceutical equivalence, ingredients, monograph, dissolution, assay, clinical trail, AUC, Cmax etc.