Twenty first century is the century of globalization, industrialization, and modernization. This advancement has led to a drastic increase in the incidence of lifestyle related diseases like Obesity, DM, HTN, Hyperlipidemia etc. eventually leading to the risk of number of chronic disorders such as cardio-vascular disease(CVD). Aim & objective: In this clinical study, we are aiming to Study the Effect of Chaturushan as dietary supplement in CVD Risk assessment as per Framingham Heart Score. Objectives:. To assess the effect of Chaturushan on Total cholesterol, Sr.HDL and Blood Pressure in the experimental group and to compare the same for Gomutra Haritaki(GH) which is an already proven drug and taken here as a control. Materials & Methods: In this study 60 patients of Dyslipidemia bearing a risk of cardio-vascular disease were selected by using selection criteria irrespective of age, sex, and socio-economical status. In Group A (n = 30), patients were administered Chaturushan churna 2gm daily in 2 divided doses. for 3 months and in Group B (n = 30), Gomutra Haritaki churna was given in similar dose and duration. Effect of therapy was assessed objectively by Framingham Heart Score including Total cholesterol, Sr.HDL, Systolic and Daistolic BP. Also, Physical parameters like body weight, waist circumference and Body Mass Index (BMI) were assessed and subjectively by the cardinal symptoms.After completion of therapy all values were recorded and statistically analyzed and results were obtained. Conclusion:Chaturushan a dietary supplement was found quite effective in lowering the Total cholesterol levels as per FHS But, on comparing the effects of the two groups subjectively, it can be concluded that both the supplements are equally effective in reducing the subjective scores of the disease.