The present study deals with influence of Brain Based Learning (BBL) approach on academic achievement of Standard VII students in science. For the study true experimental design was used, by selecting two intact divisions of Standard VII from same school, each of 43 students. An intervention programme based on the BBL principles, fundamentals, and seven stage lesson plan was prepared. The data was analysed with descriptive and inferential statistics, using SPSS software. The results obtained herein imply that the BBL intervention programme leads to significant enhancement in student’s achievement in science, which is attributed provision of interactive, challenging, and stress-free class environment. Moreover, the science teachers felt that BBL approach be adopted for other subjects and standards.