Plants are natural remedies and have been used as food and medicine by humans on earth since ancient times. Today there are efforts to find herbal medicines in plants in order to bring them to market through a drug delivery system suitable for humanity. The basics idea behind it is that the cure for every disease is hidden in nature. However, herbal drug delivery also requires modifications with the purpose to achieve sustained release, increase patient compliance, etc. So far, herbal medicines have failed to attract scientist’s changes to new drug delivery systems due to difficulties in processing, standardization, extraction, and identification. But now days with the technological advances, new drug delivery systems (NDDS) open the door to the development of new herbal medicines system. Using advanced techniques to protect against toxicity, enhance stability, improve bioavailability of herbal formulations, protection against physical and chemical degradation can be achieved. New drug delivery technologies have gained prominence to achieve the modified release of herbal medicines to increases their therapeutic value and decreases their toxicity. Current ratings provide insight on various new techniques used to improve the safety and efficacy of phytomedicines and the application of new formulations. The most important goal for developing such delivery systems is to minimize drug degradation and loss, and to prevent and increase harmful side effects biological availability. Targeting is the ability to direct the drug-laden system to the location of interest. Among the drug carriers there are solubles polymers, micro particles consisting of insoluble (or) biodegradable natural and synthetic polymers, microcapsules, cells, ghost cells, lipoproteins, liposomes and micelles. Two main mechanisms can be distinguished for targeting the desired drug delivery sites, (a) passively and (b) Active targeting. Controlled drug delivery systems, such as micellar solutions, vesicles and liquid crystal dispersions, as well as nanoparticles Dispersions consisting of small particles of 10-400 nm are promising as drug delivery systems. Hydrogels are three-dimensional, hydrophilic polymer networks capable of absorbing large quantities of water or biological fluids. Key words: Novel drug delivery system, Phytosome, Nanoparticle, Microsphere, Transdermal drug delivery system carrier, Colloidal drug delivery system