Hyperkalemia associated with the antihypertensives is a leading condition among the hypertensive individuals especially those who are suffering from chronic hypertension and other metabolic disorders like diabetes mellitus and obesity. The combination of therapies of high dose of Hydrochlorothiazde, Valsartan and Amlodipine for last two years given to the patient leads to severe adverse effects some of which are irreversible. In this case a female patient of age 62 years appeared in emergency with severe vomiting, nausea, SOB (shortness of breath), pulmonary edema and arrhythmia. ECG shows prolongation of the PR and QRS intervals, and her laboratory reports were showing increased creatinine, serum urea level and a very high potassium level. She was given symptomatic treatment to treat her symptoms and later on she was undergone hemodialysis to remove the excessive potassium from her body and she got recovered later on. Key words: Associated, combination, high dose, Irreversible, Excessive.