Lumpy skin disease is a disease caused by the capri pox virus belonging to the family pox viridae. The disease has recently created havoc in the livestock sector by causing high mortality in cattle. This disease was first reported in India on 18th of November, 2019 in Odisha. The disease was responsible for great economic loss in terms of mortality, decreased milk production and other dairy products. The diagnosis of the disease was carried out by viral isolation and confirmation was made using different molecular techniques such as the fluorescent antibody test, polymerase chain reaction, ELISA and other techniques. The treatment protocol followed consisted of the conventional and ethno-veterinary approach as per the guidelines of the national dairy development board (NDDB). Through different approaches, efforts were made to control the transmission of the virus and improve the health of the livestock.