The dependence of frustration in twenty main social spheres in men and women with high and low levels of self-assessment of health was studied. Between men and women with normal and low self-esteem of health, there are differences in the specifics of experiencing the state of social frustration in the areas of: 1) professional communication; 2) the content of their work; 3) assessment of their housing and living conditions; 4) communication with parents, and 5) leisure activities. In these five areas, with a decrease in self-esteem of health, women show significantly more frustration than men.