The issues of formation of mechanisms for the implementation of integrated scientific and technical research and development attract the attention of not only scientists, but also business representatives, which is associated with an understanding of the importance of the innovations impact and scientific achievements on socio-economic development through structural changes in the knowledge economy. Despite the existing research, this scientific problem requires a more detailed study, since it is of particular importance in the context of the development of the digital economy, in which knowledge and information are the main resources that affect competitive advantages. A comparative analysis of the mechanisms for the implementation of complex scientific and technical research and development has been carried out. Methods and tools for assessing the innovative and scientific and technical potential of integrated research and development are proposed.