Several screening tests were carried out to evaluate drought resistance in total 12 wheat (Triticum L.) genotypes. As a result of PCR using RAPD markers it was found out that primer P6 produced 920 bp band in drought tolerant genotypes in comparison to sensitive ones (Garagylchyg-2, Giymatli-2/17 and semi-tolerant Gyrmyzy gul). Primer P7 produced a 750-bp band that is not absolutely universal for our genotypes. Genome-wide investigation was also conducted using Dreb 1 genes as an example. P21F/P21R primer amplified 1113 bp fragment in all tested genotypes, excluding Tale-38, suggesting that in these genotypes Dreb 1A gene is located on the third chromosome of A genome. The P18F/P18R primer amplified a 717 bp fragment from the B genome. It was found out that Dreb 1 gene was located on chromosome 3A in all genotypes, including drought-tolerant and drought-sensitive ones, excepting semi-tolerant genotype Tale-38. Contrary to other genotypes, a 717 bp PCR product of Dreb 1B gene was located on B genome from drought-tolerant variety Barakatli-95. Primers P22F/PR and P20F/P20R that amplify 596 and 1193 bp fragments, respectively, from D genome, that is common for hexaploid Triticum aestivum L. genotypes, did not reveal positive results.