The paper provides information about the threatened plants in Shusha and the surrounding areas. According to obtained data, 233 rare species of higher plants of various groups found in the Karabakh and Eastern Zangezur economic regions can be included in the future "Red Book of Karabakh”. 59 species of them are (28 families and 49 genera) endemic, sub endemic and rare plants found in Shusha and the surrounding areas. 33 of these species (15 families, 27 genera) were first described in Shusha and its surroundings (12 species were first described directly from Shusha (10 families, 11 genera). The article describes the features (priority name, morphological features, nomenclature type, distribution, ecological features and importance) of 12 species, described directly from the surrounding areas of Shusha.