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Pharmacological activity of amino acids and prospects for the creation of drugs based on them

Authors: Davydova, I.O.; Ruban, O.A.; Herbina, N.A.;

Pharmacological activity of amino acids and prospects for the creation of drugs based on them

Abstract

{"references": ["Amino acids. MedlinePlus Encyclopedia. The 9 essential amino acids are: histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. 2015", "Hou Y., Yin Y., Wu G. Dietary essentiality of \"nutritionally non-essential amino acids\" for animals and humans. Exp Biol Med (Maywood). 2015. Aug. Vol. 240 (8). P. 997-1007.", "De Koning T. J. Amino acid synthesis deficiencies. Handb Clin Neurol. 2013. Vol. 113. P. 1775-1783.", "WHO. Protein and Amino Acid Requirements in Human Nutrition. In: WHO/FAO/UNU, editor. Geneva: World Health Organization. 2007. P. 276.", "Compendium. URL: https://compendium.com.ua/ (date of application: 09.06.2022)", "State Register of Medicinal Products of Ukraine URL: http://www.drlz.com.ua/ (date of application: 11.06.2022)", "Biochemistry: textbook / ed. E. S. Severina. 5th ed., rev. and add. M.: Geotar-Media, 2015. 768 p.", "Syrovaya A. O., Shapoval L. G., Makarov V. A., Petyunina V. N., Grabovetskaya E. R., Andreeva S. V., Nakonechnaya S. A., Bachinsky R. O., Lukyanova L. V., Kozub S. N., Levashova O. L. Amino acids through the eyes of chemists, pharmacists, biologists: in 2 volumes. Volume 1. Kh .: Generous manor plus, 2014. 228 p.", "Syrovaya A. O., Shapoval L. G., Makarov V. A., Petyunina V. N., Grabovetskaya E. R., Andreeva S. V., Nakonechnaya S. A., Bachinsky R. O., Lukyanova L. V., Kozub S. N., Levashova O. L. Amino acids through the eyes of chemists, pharmacists, biologists: in 2 volumes. Volume 2. Kh .: Generous manor plus, 2015. 268 p.", "Lysikov Yu. A. Amino acids in human nutrition. Experimental and Clinical Gastroenterology. 2012. Vol. 2. P. 88 \u2013 105.", "Garlick P. J. The role of leucine in the regulation of protein metabolism. J. Nutr. 2005. Vol. 135. 1553-1556.", "Hou Y., Wu G. Nutritionally Essential Amino Acids. Adv Nutr. 2018. Nov. 01. Vol. 9 (6). P. 849-851.", "Marakhovsky Yu. H. Amino acids as medicines: from scientific achievements to clinical practice. Experimental and Clinical Pharmacology: Proceedings of the 3rd International Scientific and Practical Conference. Minsk. June. 2009. P. 27-34.", "Long-term effects of leucine supplementation on body composition / Balage M., Dardevet D. Curr. Opin. Clin. Nutr. Metab. Care. 2010. P. 265-270. doi: 10.1097/MCO.0b013e328336f6b8.", "Wu G. Functional amino acids in nutrition and health. Amino Acids. 2013. Vol. 45. P. 407-411.", "Novel metabolic and physiological functions of branched chain amino acids: a review / Zhang S., Zeng X., Ren M., Mao X., Qiao S. J Anim Sci Biotechnol. 2017. P. 8-10.", "Arany Z., Neinast M. Branched chain amino acids in metabolic disease. Curr. Diabetes Rep. 2018. Vol. 18. P. 76. doi: 10.1007/s11892-018-1048-7", "Le Floc'h N., Otten W., Merlot E. Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino Acids. 2011. Vol. 41. P. 1195\u20131205. doi:10.1007/s00726-010-0752-7", ". Firk C., Markus C. R. Mood and cortisol responses following truptophan-rich hydrolyzed protein and acute stress in healthy subjects with high and low cognitive reactivity to depression. Clin Nutr. 2009. Vol. 28. P. 266-271. doi: 10.1016/j.clnu.2009.03.002", "Dillon E. L. Nutritionally essential amino acids and metabolic signaling in aging. Amino Acids. 2013. Vol. 45. P. 431-441", "Olsen T., Ovrebo B., Turner C., Bastani N. E., Refsum H., Vinknes K. J. Combining dietary sulfur amino acid restriction with polyunsaturated fatty acid intake in humans : A randomized controlled pilot trial. Nutrients. 2018. doi: 10.3390/nu10121822", "Amino acids and immune function / Li P., Yin Y. L., Lia D. F., Kim S. W., Wu, G. Y. Brit. J. Nutr. 2007. 98. P. 237\u2013252.", "Matthews D. E., Ross A. C., Caballero B, Cousins R. J., Tucker K. L., Ziegler T.R., eds. Proteins and amino acids. Philadelphia: Lippincott, Williams & Wilkins, 2014. 3\u201335.", "Davies J. S. Aminoacids, peptides and proteins. Cambiidge: The Royal Society of Chemistry, 2006. 472 p.", "Protein quality assessment: impact of expanding understanding of protein and amino acid needs for optimal health / Millward D. J., Layman D. K., Tom\u00e9 D., Schaafsma G. Am. J. Clin. Nutr. 2008. Vol. 87. P. 1576-1581.", "Wu G. Amino acids: metabolism, functions, and nutrition. Amino Acids. 2009. May. Vol. 37 (1). P. 1-17.", "Wu G. Functional amino acids in growth, reproduction, and health. Adv. Nutr. 2010. Vol. 1. P. 31-37.", "Friedman M, Levin CE. Nutritional and medicinal aspects of Damino acids. Amino Acids. 2012. P. 1553\u20131582."]}

Introduction. Amino acids play an extremely important role in human life, as they are responsible for the normal functioning of the entire body. For full functioning, the human body uses 22 amino acids, 10 of which it synthesizes by itself, other 9 amino acids must be obtained from the outside. In the diet, it is necessary that all amino acids are presented in certain optimal ratios. Both a deficiency and an excess of one or another amino acid in the diet can lead to an imbalance, that is, to a violation of the balance of amino acids. Therefore, in cases of insufficient protein nutrition, it is advisable to enrich daily rations with essential amino acids in the form of various medicines based on them in order to prevent the negative impact of amino acids imbalance and for the normal functioning of all systems and organs. Therefore, the aim of this study was to summarize modern literary sources on the pharmacological action of essential amino acids, to analyze the existing drugs based on them on the pharmaceutical market of Ukraine, to substantiate the prospects and feasibility of their further inclusion in the composition of drugs for the prevention and treatment of pathologies of various systems and organs. Material & methods. The methods of marketing analysis, comparison and generalization of information were applied. The following sources were used as information materials on medicinal products: the directory of pharmaceuticals "Compendium on-line" and the State Register of Medicinal Products of Ukraine. Results & discussion. Based on the results of the analysis, it was established that the majority of medicinal products on the pharmaceutical market of Ukraine are manufactured by domestic pharmaceutical enterprises. A smaller share of medicines is imported from other countries of the world. The analysis of medicinal products by composition showed that the majority of drugs are monopreparations. According to the results of the analysis, in most cases, drugs based on amino acids are presented in the form of infusion drugs, a smaller share is allocated to solid dosage forms. Conclusion. The analysis of the pharmaceutical market of drugs based on amino acids showed that, in general, infusion drugs prevail, which are usually prescribed to patients with acute deficiency of amino acids. However, today's realities indicate the impossibility of a balanced diet for most categories of people, which indicates the need to use drugs based on amino acids in more convenient dosage forms. it is advisable to develop new domestic medicines in solid dosage forms based on them for the prevention and treatment of pathologies of various systems and organs, which will ensure ease of use and help eliminate the deficiency of amino acids in the body. Solid dosage forms are convenient, do not require special conditions for use, and often ensure the beginning of the process of absorption by the mucous membrane of the oral cavity. All this is the reason for the prospect of expanding this segment of the pharmaceutical market.

Keywords

amino acids, research, market analysis, solid dosage forms

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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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impulse
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