Natural polymers like locustbeangum, banana powder, mangopeel pectin, Mangifera indica gum, and Hibiscus rosa-sinenses mucilage ameliorate the propertiesof tablet and utilized as binder, diluent, and superdisintegrants increasethe solubility of poorly water-soluble drug, decrease the disintegration time, and provide nutritional supplement. Present investigation aim to formulate Roxithromycin fast dissolving tablets using natural polymers. The % drug content of all the formulated tablets were found within the limit. % drug content value of Roxithromycin was within 97.85±0.25%to99.65±0.24%. The results within the range indicate uniform of mixing. The Table no 7.6 shows the %drug content in each formulation. The In vitro drug release studies of the enhanced detailing was subjected to integrity of fit test by linear regression analysis as indicated by zero order, first order kineticandHiguchireleaseequation, inordertodecidethemechanismofdrugrelease. When the regression\ coefficient values of were compared, it was observed that ‘r2’ values of First order release kinetics was maximum i.e. 0.996 hence indicating drug release from formulations was found to follow First order release kinetics. Key words: Roxithromycin, Natural polymers, fast dissolving tablets, Formulation, Evaluation