Abstract Nowadays, the development of social entrepreneurship is considered as a social and philanthropic mission, and one of the ways to solve some problems and social harms. Entrepreneurship has had a positive and future impact on many different activities of countries; On the other hand, it can cause economic development and create job opportunities, and on the other hand, it can improve the social and cultural condition of the society. The present study aimed to design a model to explain the social responsibilities of universities based on the approach of social entrepreneurship in the universities of Khuzestan province. The present research method was a developmental-exploratory study. The statistical population of the research included 30 university professors using purposive sampling and the brainstorming method (interview with experts) and it continued until it reached theoretical saturation. In this research, it has been used the Delphi method based on the identification of the central phenomenon, causal conditions, contextual and intervening factors, strategies and consequences and the relationship between them. Examining the data obtained in the first stage of open coding, 36 concepts about social entrepreneurship and 48 concepts about social responsibility were obtained.