The practice of sexed semen in livestock production and genetic improvement has shown to be achievable with variable degrees of efficiency during several species and proved to be economically viable in cattle. Sexed semen is a reproductive technology intended to change the sex ratio of the offspring toward a preferred gender. Though along with various advantages, this technology has some constraints also, as discussed in this article, these can be overcome by using suitable practices for optimizing conception rates of sex-sorted semen.