The changing nature of knowledge in recent times is argued to be a key reason why educators need to consider curriculum integration. Curriculum integration is a curriculum design that repositions subject content through collaboration and experience in order to increase its meaning and relevance to students, holding less regard for disciplinary boundaries than traditional didactical approaches. The purpose of this research is to study the effectiveness of Integrated Curriculum Approach (ICA) in the learning of science among the secondary school students. In order to test the effectiveness of the approach across the different boards namely SSC, CBSE and CIE the researcher adopted an experimental study. The sample for the study consisted of 260 students of English medium Secondary Schools affiliated to SSC, CBSE and CIE board from Mumbai and Navi Mumbai. A multivariate analysis ANOVA employed to evaluate results of the study. The significance of the approach with the integrated system were tested using t test.