The objective of the present work is to formulate and evaluate buccal films of domperidone using natural(dehydrated banana powder, Hibiscus mucilage), synthetic(sodium starch glycolate) and semi synthetic(Croscarmellose) super disintegrants. Preliminary studies were conducted for the pure drug and other excepients. The FTIR studies revealed that there was no interaction between drug and excepients. As Domperidone belongs to BCS class II having low solubility, its solubility gets enhanced by complexation with Hydroxy propyl beta cyclodextrin by kneading method. These complexes were used to prepare buccal films by solvent casting method. The prepared buccal films were evaluated for Disintegration time,folding endurance,weight variation etc.The dispersion studies were done in pH 6.8 phosphate buffer. The work has done to study the effect of super disintegrants on the disintegration time of the buccal films.