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Abstract There are numerous investigations of the fluids flow in the small-sized channels in the reference. It is shown that the experimental results of hydraulic resistances in these channels are more than the estimated ones according to theoretical formulas. There are given supposed different explanations without quantitative estimation. The numerous experimental results in the reliable setting are given in this work. Firstly, the experimental-estimated methodology for “microcrack-fluid” system has been proposed and realized for the quantitative estimation of the hydraulic resistances. This approach allows to conduct hydrodynamic engineering evaluations for fluid flow in the cracked-porous medium, for lubrication in the systems of mechanical engineering, instrument engineering and also for solutions of the sealing problems in different branches of industry and medicine.