ABSTRACT The cellulose activity in different polluted and control soils in Warangal city are analyzed during June 2013 to May, 2014. The minimum and maximum cellulase enzyme levels were 10.13 mg/L to 26.32 mg/L in the near nayeem nagar sewage canal, while this range was 13.17mg/L to 29.12 mg/L in the soils amended with dairy industry waste water flooded soil. The minimum and maximum range of cellulose activity was 13.9 mg/L to 24.84 mg/L in aluminum industry waste water flooded soil. The cellulose enzyme activity range in soil amended with tannery industry waste water flooded soil was 10.91 mg/L to 16.5 mg/L, while the range of activity was 14.3 mg/L to 31.21 mg/L in control soils.