Background: Stroke is a disease of paramount public health significance. The role of plasma fibrinogen in determining incidence and severity of stroke has been postulated time and again. Present study was undertaken to determine the correlation between mean plasma fibrinogen level and infarct volume on CT scan in patients with acute stroke. Methods: Source of data: Plasma fibrinogen of 50 consecutive patients presenting with acute stroke admitted in Netaji Shubhas Chandra Bose Medical College & Hospital, Jabalpur from March 2019 to August 2020 and compared with 50 controls not suffering from stroke with matched age, sex and risk factors (controls) such as heart disease, hypertension, Diabetes and obesity, smoking and use of alcohol. Method of collection of data. The study will be carried out on 50 consecutive patients admitted to N S C B Medical College & Hospital, Jabalpur with acute stroke within 24 hours of the onset of symptoms. Detailed history will be taken to find out the risk factors such as hypertension, diabetes, smoking and alcohol consumption. Hypertension will be diagnosed by JNC VII criteria. Diabetes will be diagnosed by American Diabetes Association criteria. Smoking will be recorded in terms of number of cigarette pack years smoked. Thorough general and systemic examination will be carried out. In addition to routine investigations as per standard protocol in the evaluation of stroke patient, fasting plasma fibrinogen level is estimated and compared to age sex and risk factors matched controls. Result: In this study Fibrinogen levels among patients of stroke were estimated. Data on demography (age, sex, habit of smoking, tobacco and alcohol) and clinical parameters (BMI, heart disease, Hypertension and Diabetes) was also collected. All 50 patients of stroke cases was compared with 50 control subjects, matched for age, sex, obesity, clinical parameters like heart disease, hypertension and diabetes and also for habits of smoking, tobacco use and alcohol.