ABSTRACT: The farmer population was isolated by the absolute selection, in the climatic conditions of the Fergana Valley (2551). Of these, 2478 (men – 1270 and women – 1208) were fully examined. Participation in the study was 96.6 percent. The prevalence of common risk factors in a farmer population using epidemiological, survey, biochemical, and instrumental methods are characterized by high rates and have gender–age characteristics. Risk factors vary sharply with age and increase. Farmers have developed inconsistent epidemiological conditions predisposing them to pre–urolithiasis and urolithiasis, and hence their correction leads to success in primary and secondary prevention.