This case study is part of a series shining a light on the experiences of immunization and primary healthcare staff working at different levels of national immunization programmes in low- and middle-income countries. The people featured are all taking part in the peer learning programme organized by the Geneva Learning Foundation (LinkedIn | YouTube | Twitter | Podcast). A community-based approach that helped to increase vaccination coverage in conflict-affected areas of Cameroon is now being applied more widely across the country. “When I was the EPI Coordinator for the South-West region of Cameroon, insecurity led to a big drop in vaccination. We had been doing well, achieving coverage of 86%, but due to the insecurity this fell to around 40%. With support from WHO and UNICEF, we attempted to mobilize community participation in order to build coverage back to previous levels. In 2020, we undertook periodic intensification of routine immunization (PIRI) activities during security windows, through which we were able to increase DTP3 coverage by 28%. Despite the impact of insecurity, the COVID-19 pandemic and curfews, we also managed to vaccinate 14/40% [to be clarified with NAT] of adolescent girls with human papillomavirus vaccine (HPV) within 3 months of its introduction, and reached 43% of our target population for a newly introduced second dose of measles–rubella vaccine. These were the best performances for new vaccine introductions in the country. This Immunization Agenda 2030 (IA2030) case study is part of the IA2030 Movement’s Knowledge-to-Action Hub. Learn more about the Hub… Learn more about the Movement…