The study aimed at identifying the effectiveness of Blended Learning Course for developing Techno-pedagogical skills among B.Ed. Student-teachers of the University of Mumbai. Moodle based Blended Learning Course is developed by the researcher and thus the treatment for developing Techno-pedagogical Skills is given to the experimental group. It has been found that there is significant improvement in the Techno-pedagogical Skills after the treatment. ω2 (Omega square) estimated value for Techno-pedagogical Skills is 22.61%which implies that the proportion of variance in gain scores of Techno-pedagogical Skills is due to Blended Learning Course. The effect size found maximum (Magnitude 1.8) after calculating Wolf’s formula which implies that the Blended-Learning Course has maximum effect on the development of the Techno-pedagogical Skills among B.Ed. Student-teachers.