This research was carried out to determine the effect of music therapy to fatigue and anxiety levels in hemodialysis patients. Research was carried out as a semi-experimental model with pre-test-post-test control group. The study was composed of patients treated in the dialysis service at Gazi Yasargil Training and Research Hospital in Diyarbakır, Turkey ), from December 2018 - January 2020. 120 patients, 60 experimental and 60 control groups, were participated. Patient Information Form, Fatigue Severity Scale, State-Continuity Anxiety Scale were applied to the experimental and control groups after pre-test, after music therapy to experimental group. While, Fatigue Severity Scale, Statefulness-Continuity Anxiety Scale was applied to control group one week later without any intervention. In the analysis, T test was used in dependent and independent groups. The mean fatigue intensity score of patients in experimental group decreased from 54.78 ± 6.39 before intervention to 23.45 ± 4.44 after intervention. There was a significant difference between mean scores. Experiment and control groups were compared and found that there was significant difference between groups. In the study, it was found that levels of fatigue severity and state anxiety of individuals with dialysis patients decreased after music treatment.