Principals play central role in cultivating college environment that supports quality and innovative educational practices. The review shows that individual with Higher Self – Efficacy approaches difficult tasks as a challenge. The aim is to find the level of self - efficacy and to compare self - efficacy among the principals of professional and non – professional courses. Normative survey method is used and the area covered is Maharashtra state in India. Professional courses considered are from Pharmacy, Law and Education. Non-professional courses considered are from Arts, Science and Commerce. Total 245 Principals are selected randomly as a sample. The tool used is Self-efficacy Scale by G. P. Mathur and R. K. Bhatnagar. Collected data are analyzed using statistical measures to draw conclusions. The findings shows a significant difference in self – efficacy of principals of Professional courses and non-professional courses.