The present study relationship between loneliness & Mental Depression among college students. Loneliness and mental depression is an important factor for mood when people feel lonely that time he suffer depressed mood that time people do the suicide attempt . A sample of 80 college student located Pune hadpasar District, age range 20to 21 years. Loneliness Inventory constructed and developed by Uma, Meenakshi under the guidance of Krishnan measure Loneliness. Mental Depression measure mental depression this test constructed dubey. Research design t test and correlation analysis. Result relevant that significant of relation between loneliness & mental depression and other hypothesis gender difference loneliness & mental depression of college student.