The major problem in drug manufacture nowadays is that many bacteria have evolved and became resistant to some particular drugs, these bacteria are referred to as multidrug resistant bacteria (MDR). The major reason for this being the overuse of antibiotics for the healthcare of people in the recent past. These multidrug resistant bacteria have reduced the efficiency of already existing drugs and also increased the expenditure of newer drugs and healthcare facilities. Therefore, novel and effective new drugs and innovative new therapies are urgently needed to treat MDR infections. From ancient times people have always tried to find cure for their health-related problems from the nature and the same has been the case in finding a solution to these multidrug resistant bacteria. So, in recent times studies have been conducted on different phytoconstituents like flavonoids, alkaloids, tannins, phytosterol etc. of plant origin to check their antimicrobial property against multidrug resistant bacteria. The Middle East comprises of a wide spectrum of plant diversity with over 20,000 different species in habitats ranging from deserts to snow-capped mountains. This review will help in considering certain phytoconstituents for preparation of drugs against multidrug resistant bacteria and solving this increasing problem which is to make drugs against multidrug resistant bacteria.