A Compendium of Open Access/Open Science Policy Case Studies from African Higher Education Institutions for the LIBSENSE Open Science policy development workshops convened as part of activities in the AfricaConnect3 programme. The case studies in this compendium have been solicited from partners throughout Africa by the LIBSENSE policy working group. They represent a broad range of open access/open science policy development initiatives from those involved in developing and implementing them. The representative universities cover a range of public and private institutions where research activity occurs. Altogether, they give perspectives on OA/OS policy development at the institutional level, including the motivations, successes, challenges and outcomes. This compendium also includes one case study outlining policy development efforts coordinated at a regional level in Francophone Africa. Through these workshops, LIBSENSE envisages an opportunity to align institutional level policy with ongoing efforts to deliver on national open science roadmaps as part of the broader Open Science agenda that LIBSENSE wants to achieve across Africa. It is also the impetus for its alignment with UNESCO’s Recommendations on open science, embracing its own Open Science vision on implementing UNESCO open science principles in an African context. In support of this, the compendium includes a recommended checklist for universities to follow when implementing UNESCO recommendations on open science.