This paper examined senior school certificate examinations as predictor of students’ academic performance in mathematics in southeast Nigeria universities. It also revealed the relationship between the academic performance of students in each level of the university examinations and their corresponding secondary school certificates examination. A total of 275 2018/2019 part 4 mathematics students that sat for SSCE and had complete records from part 1 to part 4 were involved in the three selected south-east universities. Ex post facto design was adopted. The grades of all the mathematics students sampled were collected from the office of admission while the cumulative grade point average were collected from department of the sampled universities. The results revealed there was relationship between SSCE mathematics scores and academic performance of mathematics students at all levels in the universities. The results also showed that there was no influence of the mode of entry on the academic performance in all levels and the two examining bodies were equivalent. Based on this finding, it was recommended that both West African Examination Council (WAEC) and National Examination Council (NECO) should be used as mode of entry into mathematics department.