The current study was done to assess the perceived learning needs and readiness for hospital discharge of patients with Acute MI and to identify the association between perceived learning needs and readiness for hospital discharge with selected socio demographic variables. The sample consisted of 100 patients with acute MI selected by convenience sampling technique. The descriptive research design with quantitative approach was used. The tools for this study were Structured Questionnaire on socio demographic data, MI patient’s learning need Rating Scale and RHDMIS Scale to assess the perceived learning needs and readiness for hospital discharge respectively. The data was analyzed with descriptive and inferential statistics. The findings of the study showed that the very important aspects of perceived learning need of patients were recognizing signs and symptoms of complication early (69%), doctor’s instructions for self-care (61%), type of diet (54%) and action and side effect of medication (54%).The samples considered effect of disease on sexual life (65%) as least important perceived learning needs. The study revealed that, the readiness for hospital discharge had a mean score of 56.This implies that acute MI patients had medium level of readiness for hospital discharge. The mean percentage score of readiness for hospital discharge of acute MI patients were high (85.71%) in the aspect of subscale 1.There was no significant association between perceived learning needs and readiness for hospital discharge with the selected demographic variables. The present study concluded that the proper assessment of perceived learning needs could improve the readiness for hospital discharge and thus the quality of life.