This is a descriptive type analytical cross-sectional study. it was conducted to assess the nurses knowledge and practice regarding care of acute severe asthmatic children. 50 nurses were enrolled in the study after thorough informed consent and approval from the ethical review board of the The Children’s Hospital and Institute of Child Health Lahore, Pakistan. A pre-tested and pre-coded questionnaire consisting of 11 questions was handed over to the volunteers. their experience in paediatric unit ranged from below 5 year to more than 10 years; their qualification was graded accordingly. The study revealed that most of the nurses (70%) knew the definition of asthma and more than 3/4th (80%) of nurses have knowledge about giving oxygen therapy during severe acute asthma attack and (76%) of nurses knew the nutritional care of asthmatic patient; regarding performance of nursing skills of asthma most of nurses (56%) of nurses did not know to perform spirometry procedure, instead of (82%) of nurses know how to give oxygen to asthmatic patient, the study recommends that hospital administration, stake holders and policy makers should develop continues education programs and workshops for the health care providers to optimize the knowledge and practice of the nurses and boost the efficient skill development. Installation of educational posters and management flowcharts in nurse’s office can prove to be a valuable interventional strategy to combat the dilemmas regarding asthmatic patient. Keywords: Asthmatic Child, Acute Severe Asthma, Nurses Knowledge, Child Health.