Nigella sativa has been used and known as medicinal plant on wide range in whole world. Black seeds utilize in different recipes of edible food. Black seed is also utilized to treatment of various ailments has been used on wide range. It has been useful and effective for treatment of diseases like, antihypertensive, diuretics, anti-diarrheal, betterment of appetite by acting as stimulus, antimicrobial, disorders of skin and as liver tonic. Considerable study on N. sativa has been conducted by different researchers and large number of pharmacological usefulness has been explored which include anti-covid-19, Immunomodulator, anti-bacterial, bronchodilator, anti-inflammatory, hepato-protective, renal infections, antioxidant, anticancer and antidiabetic properties etc. Black seed has miraculous power because of which it has top ranked evidenced position in herbal medicinal based treatment. It has been explored that plants having thymoquinone compound have effective therapeutic properties. Thymoquinone is a main bioactive component present in essential oil. Current review is conducted to compile a detailed of scientific data conducted about pharmacogenetic properties, chemical manufacturing as well as pharmacological effectively of N. sativa seeds.