From the emergence of species, human and animals had established mutual relationships. Societies have evolved different methods of engaging with local fauna for traditional purpose. Zootherapy is an essential part of ethnozoology. To cure wide range of illness, animals and by- products are used by local inhabitants. Mammals, fishes, birds, reptiles and amphibians, insects are endowed with significant therapeutic properties. Different civilizations have utilized animals and animal products such as hooves, hides, feathers, tusks for traditional medicine preparation since prehistoric times. In the modern era, animal-based therapy is an important alternative among many other methods of treatment known in the world. Traditional knowledge generally refers to the knowledge, innovations and practices of indigenous and local communities involved in genetic resources, developed from the experience of communities over many centuries, adapted to local needs, culture and environment and passed down orally from generation to generation. Fast environmental, technical and socioeconomic changes make it more likely that this knowledge might be forgot by the future generations, the only way to preserve it is doing documentation.