Database containing the vulnerability indicators used in the holistic analysis of vulnerability to flash floods in the region of Castilla y León (Spain), considering all its dimensions (social, economic, ecosystem, physical, institutional and cultural) and components (exposure, susceptibility and resilience). The database contains a total of 496 variables, of which 216 characterize social vulnerability, 180 economic vulnerability, 49 ecosystem vulnerability, 22 physical vulnerability, 23 institutional vulnerability and 6 cultural heritage vulnerability. The Excel file contains two sheets for each vulnerability dimension. The first sheet (whose name is composed with the name of the dimension and the suffix '_Variables') contains the information of the variables, i.e., the names of the municipalities, the province to which they belong and the values of the variables for each municipality. The variables on this sheet are identified as codes, whose definition and description (unit in which they are expressed, reference year of the information, information source and the link to the information) are found on the second sheet of each dimension (suffix '_Data_sources').