Organic light emitting diodes (OLEDs) are among the most efficient optoelectronic devices for multiple displays and illumination technologies. Their superior performance over conventional sources has boosted this discipline, reaching to what is considered as the 4th generation of OLEDs. These OLEDs are based on a novel concept known as hyperfluorescence (HF), in which a thermally activated delayed fluorescent (TADF) material acts as sensitizer of a narrow-band fluorescent emitter via Förster resonance energy transfer (FRET). However, HF-OLEDs still present intrinsic limitations mostly related to molecular aggregation of TADF compounds, and the FRET efficiency. Metal-organic frameworks (MOFs) are excellent platforms for developing novel HF materials to be used in the fabrication of more efficient OLEDs. Their ordered structure, joint with the possibility of using TADF molecules as organic linkers, will minimize the issues associated with molecular aggregation, while enhancing the TADF mechanism by reducing molecular motions. Moreover, their porous structure allows for the encapsulation of narrow-band emitters (HF guest@TADF-MOFs), shortening the distances between the donor (TADF-MOF) and the acceptor (narrow-band emitter), and thus, increasing the FRET efficiency. HyperFMOF intends to fabricate and fully characterize novel HF guest@TADF-MOFs, which will be subsequently integrated as emissive layers of high-performance OLEDs. This project is multidisciplinary and highly ambitious, and the overall aim will be achieved by: the synthesis and characterization of unexplored TADF linkers, TADF-MOFs and HF guest@TADF-MOFs; the in-depth investigation of their spectroscopic and photodynamics properties; and the manufacturing, characterization and optimization of novel HF guest@TADF OLEDs. HyperFMOF will open new avenues in different research areas from synthesis to spectroscopy and OLED technology, and will overcome the limitations of preceding OLED generations.

In line with the European Energy Strategy on H2020, intensified research on the development of more-efficient and cost-effective light emitting diodes (LEDs) is required. In this regard solution processable colloidal quantum dots (QDs) and metal halide perovskites (PS) showed excellent proficiency to realize effective devices with low fabrication cost on large-area and light-weight substrates. Despite the high potentiality of developing advanced LEDs by exploiting the combination of PS and QDs, the investigation of the interactions of both materials is still in its early stage; and much is yet to be discovered regarding the charge-transport dynamics, mobilities, and defect states in different compositions of these hybrid materials. Our project's research objectives address this crucial issue and focus on designing novel, lead-free, QD@2D-PS hybrids, optimize their composition through studying their electro-optical properties, and finally characterize their performance in LED devices. The project (LED4Nature) will provide detailed knowledge about the effectiveness of Sn based 2D PS as a matrix for lead-free near-IR emitting QDs, and understanding of the effect of structural modifications (QD size, shell thickness, and PS's cation) on their spatially- and temporally- resolved photo-induced phenomena by time-resolved transient absorption and femtosecond terahertz spectroscopy, along with fluorescence lifetime imaging microscopy. Such information will be essential for the optimization and acceleration in the development of LED devices based on these hybrid materials which will be achieved through planned secondments to an expert group- and is expected to have significant industrial and socio-economic impacts. Comprehension of such multidisciplinary project will not only provide the fellow excellent research training, but will also provide a skill-set of transferable skills which will improve and diversify the fellow's future employment perspectives.

The importance of tourism in Europe and its global relevance is unquestionable. Europe is the most visited tourist destination worldwide in terms of the number of countries receiving international tourism, income and employment generated, according to data from the World Tourism Organisation (UNWTO). Tourism represents one of the key and most dynamic sectors of the European economies, mainly in Spain and Italy, contributing to the generation of employment, national wealth and socio-economic development. The project is developed by a consortium of three universities from three EU countries (Spain, Italy and Romania), with lectures and seminars given by both academics of the highest scientific level and professionals of the sector. Students will benefit from a high-level scientific environment on all campuses and will have the opportunity to combine theoretical courses with practical activities such as participation in real research studies, use of simulators for the management of hotel companies and internships in companies in the tourism sector. On the other hand, with regard to professional prospects, graduates will be candidates for both doctoral and management positions in companies in the tourism sector. The professional interest of the proposed degree lies in the fact that the proposed subjects provide comprehensive, high-level and multidisciplinary training in the tools and processes of management and management of tourism companies, activities and institutions. To this end, training is provided based on the the development of personal skills and attitudes that enable professionals to efficiently design, build, organise, maintain and manage a tourism company, and boost the competitiveness of their organisations, within the principles of sustainable development that guarantees the well-being of society as a whole. In addition, the internships provided by the partners will allow students to create connections that will guarantee their professional development.

Prostate cancer is the second most common diagnosed malignancy and the fifth leading cause of cancer mortality in men. Whilst primary tumours respond well to therapy, tumours in the metastatic setting become inherently resistant to chemotherapy. Thus, more novel and effective therapeutic approaches are highly needed to treat this lethal disease. The cornerstone treatment for advanced prostate cancer consists of androgen deprivation therapy and docetaxel (DTX). However, both DTX activity and Androgen receptor (AR) signalling are highly interrelated. On the one hand, it has been shown that DTX is able to inhibit Androgen Receptor (AR) signalling and on the other hand, the activation of AR signaling can induce DTX insensitivity. In order to break this dependency of DTX effectiveness on AR signaling and ensure efficient treatment for advanced prostate cancer, we propose the selective inhibition of AR deploying CRISPR/Cas9 technology together with DTX. Both therapeutical approaches will be encapsulated into prostate-specific targeted nanoparticles which will allow the simultaneous delivery of the drug and CRISPR plasmids targeting AR into the tumour site. The designed state-of-art multi-functional nanoparticles will reprogram and sensitise the prostate tumour to DTX in situ, and will also induce a higher accumulation of the treatment in the tumour while healthy tissues will remain less affected. Moreover, the use of CRISPR/Cas9 will precisely engineer the prostate cancer cells to express lower levels of AR, contrasting with current anti-AR treatments, which have multiple off-targets. This approach represents an innovative targeted therapy for advanced prostate cancer. It will allow the administration of lower doses of chemotherapy with consequently reduced toxicity and the potential for longer tolerated treatment periods, whilst improving efficacy by selectively suppressing the molecular pathways causing cancer survival and resistance to treatment.