QSAR Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh, India E-mail : akanchha _ au@rediffrnail. corn Manuscript received 11 April 2008, revised 24 April 2008, accepted 6 May 2008 Quantitative Structure-Activity Relationship (QSAR) studies were performed on CYP26A1 inhibitory activity using physico-chemical parameters like Balaban centric index (BAC), mean Weiner index (WA), Balaban distance connectivity index (J), information theoretic index (ld), zero order (0χ), first order (1χ) and second order (2χ) of molecular connectivity, polarizibility (Pz) and partition coefficient (log P) along with appropriate dummy parameter. The QSAR models were tested for their statistical significance and reliability by using leave one out cross validation method. Some significant models have been reported.